Physical Nanoindentation: From Penetration Resistance to Phase-Transition Energies

Phase Transition Behavior: from Decision to

Phase Transition Behavior: from Decision to Optimization

Transition from physical activity to inactivity increases skeletal muscle miR‐148b content and triggers insulin resistance

This study investigated miR-148b as a potential physiological actor of physical inactivity-induced effects in skeletal muscle. By using animal and human protocols, we demonstrated that the early phase of transition toward inactivity was associated with an increase in muscle miR-148b content, which triggered the downregulation of NRAS and ROCK1 target genes. Using human myotubes, we demonstrated...

Tubulin Bond Energies and Microtubule Biomechanics Determined from Nanoindentation <italic>in Silico</italic>

Microtubules, the primary components of the chromosome segregation machinery, are stabilized by longitudinal and lateral noncovalent bonds between the tubulin subunits. However, the thermodynamics of these bonds and the microtubule physicochemical properties are poorly understood. Here, we explore the biomechanics of microtubule polymers using multiscale computational modeling and nanoindentati...

Tubulin Bond Energies and Microtubule Biomechanics Determined from Nanoindentation in Silico

Microtubules, the primary components of the chromosome segregation machinery, are stabilized by longitudinal and lateral noncovalent bonds between the tubulin subunits. However, the thermodynamics of these bonds and the microtubule physicochemical properties are poorly understood. Here, we explore the biomechanics of microtubule polymers using multiscale computational modeling and nanoindentati...